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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Direct impact on cholesterol levels.
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
8
Vitamin B6 improves cholesterol and metabolism
The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women.
Addresses cholesterol treatment efficacy
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
7
Vitamin B6's role in cholesterol
Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1.
Supports potential dietary benefits
We conducted a study to understand how vitamin B6 affects cholesterol levels in weaned piglets fed a high-protein diet. Our study involved eighteen piglets that were divided into three groups, each receiving different levels of vitamin B6: none, 4 mg/kg, and 7 mg/kg, over a period of 14 days.
While we did not find any significant overall changes in growth performance, we noticed that the group receiving 7 mg/kg of vitamin B6 had notably higher levels of total protein, cholesterol, and high-density lipoprotein in their blood. This suggests that higher vitamin B6 might positively influence cholesterol levels within specific contexts.
Although some improvements were found with vitamin B6 supplementation, it's important to note that we cannot definitively claim that it directly lowers cholesterol without further investigation. The study hints at a beneficial relationship, but the exact impact remains unclear when separated from the high-protein diet context.
Overall, our findings propose that adding vitamin B6 to diets might help with cholesterol management in weaned piglets, but more research is needed to fully understand these effects without the influence of other dietary components.
While we did not find any significant overall changes in growth performance, we noticed that the group receiving 7 mg/kg of vitamin B6 had notably higher levels of total protein, cholesterol, and high-density lipoprotein in their blood. This suggests that higher vitamin B6 might positively influence cholesterol levels within specific contexts.
Although some improvements were found with vitamin B6 supplementation, it's important to note that we cannot definitively claim that it directly lowers cholesterol without further investigation. The study hints at a beneficial relationship, but the exact impact remains unclear when separated from the high-protein diet context.
Overall, our findings propose that adding vitamin B6 to diets might help with cholesterol management in weaned piglets, but more research is needed to fully understand these effects without the influence of other dietary components.
Read More
Most Useful Reviews
9.5
Effective for health
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
Read More
9.5
Boosted mood
I initially overlooked this product but was thrilled upon discovering its active ingredients. I previously ordered folic acid and B12 separately, but now I get both together and sublingually. These tablets have positively impacted my mood within half an hour after taking them.
Read More
9.5
Controlled homocysteine
I previously ordered a higher-priced version of this complex to lower my high cholesterol. After taking it consistently, my homocysteine levels dropped significantly, which I am very pleased with.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
9
Vitamin B6 may improve cholesterol
Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study.
Potential confounding factors exist.
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
Read More
9
Vitamin B6 reduces cholesterol levels
Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia.
Direct impact on cholesterol levels.
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
9
Vitamin B6 improves cholesterol levels
Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice.
Co-administered with other treatments
In our study, we investigated how Vitamin B6 affects cholesterol levels in mice exposed to Myrin®-p Forte, an anti-tuberculosis drug known to cause liver damage. Mice were divided into different groups, with some receiving combinations of Myrin®-p Forte and Vitamin B6, while others were given only the drug or a control substance.
We observed that co-administering Vitamin B6 helped improve the overall lipid profile in the mice treated with Myrin®-p Forte. The results showed a significant reduction in levels of LDL, cholesterol, HDL, and triglycerides within this group. It appeared that Vitamin B6 worked synergistically with the leaves of Maytenus royleanus, which also offered protective benefits against the drug-induced liver injury.
However, while the study highlighted improvements in specific cholesterol levels when Vitamin B6 was included in treatment, we cannot state that Vitamin B6 alone had a significant independent effect on cholesterol management, as it was always combined with other treatments.
We observed that co-administering Vitamin B6 helped improve the overall lipid profile in the mice treated with Myrin®-p Forte. The results showed a significant reduction in levels of LDL, cholesterol, HDL, and triglycerides within this group. It appeared that Vitamin B6 worked synergistically with the leaves of Maytenus royleanus, which also offered protective benefits against the drug-induced liver injury.
However, while the study highlighted improvements in specific cholesterol levels when Vitamin B6 was included in treatment, we cannot state that Vitamin B6 alone had a significant independent effect on cholesterol management, as it was always combined with other treatments.
Read More
8
Vitamin B6 enhances growth and cholesterol
Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi).
Study explores vitamin B6 effects
We assessed the impact of vitamin B6, or pyridoxine, on the growth and lipid metabolism of mandarin fish. By feeding these fish diets supplemented with various levels of pyridoxine over eight weeks, we aimed to see how this vitamin could help manage their cholesterol levels.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
Read More
8
Vitamin B6 improves cholesterol and metabolism
The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women.
Addresses cholesterol treatment efficacy
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.8
9.5
Improved cholesterol levels
Superb! I take it periodically to address my high cholesterol and correct anaemia. This supplement is highly effective. Following its use, my lipid profile improved significantly, and my tests indicated a reduction in cholesterol levels. Exercises and diet modifications helped, but the supplement produced even better results.
Read More
9.5
Effective for health
A very good, effective product. It combines Methylfolate and B12 in active forms, and the taste is pleasant. It enhances absorption and assists with high cholesterol and anaemia. I have noticed improvements in my overall wellbeing and mood.
9.5
Boosted mood
I initially overlooked this product but was thrilled upon discovering its active ingredients. I previously ordered folic acid and B12 separately, but now I get both together and sublingually. These tablets have positively impacted my mood within half an hour after taking them.
9.5
Controlled homocysteine
I previously ordered a higher-priced version of this complex to lower my high cholesterol. After taking it consistently, my homocysteine levels dropped significantly, which I am very pleased with.
9.5
Effective supplement
This is an excellent supplement for lowering high cholesterol levels, which significantly reduces the risk of serious cardiovascular diseases. I highly recommend it!
